Defining rotating shift work as working at least three nights per month in addition to days or evenings in that month, respondents were asked how many years they had worked in this way. After excluding women with pre-existing CVD or other than non-melanoma skin cancer, 74,862 women were included in this analysis. Night shift information was collected in 1988, at which time 85,197 nurses responded. female nurses aged 30-55 years, who have been followed up with biennial questionnaires. The NHS, which is based at Brigham and Women's Hospital, began in 1976, with 121,700 U.S. There was no association between rotating shift work and any cancer mortality, except for lung cancer in those who worked shift work for 15 or more years (25% higher risk). CVD mortality appeared to be 19% and 23% higher for those groups, respectively. Mortality from all causes appeared to be 11% higher for women with 6-14 or ≥15 years of rotating night shift work. Using data from the Nurses' Health Study (NHS), the authors analyzed 22 years of follow-up and found that working rotating night shifts for more than five years was associated with an increase in all-cause and CVD mortality. There is substantial biological evidence that night shift work enhances the development of cancer and CVD, and contributes to higher mortality.Īn international team of researchers investigated possible links between rotating night shift work and all-cause, CVD, and cancer mortality in a study of almost 75,000 registered U.S. Sleep and the circadian system play an important role in cardiovascular health and antitumor activity.
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